The Infection Prevention and Control (IPC) Assessment Framework (IPCAF) is a tool to support the implementation of the World Health Organization (WHO) Guidelines on core components of IPC programs at the acute healthcare facility level. Before using this tool, the user should be familiar with these guidelines, including the Interim practical manual supporting the implementation of the IPC core components at the facility level. The IPCAF is a systematic tool that can provide a baseline assessment of the IPC programme and activities within a health care facility, as well as ongoing evaluations through repeated administration to document progress over time and facilitate improvement.